ABSTRACT
Objective:To investigate the correlation between serum cystatin C and formation of intracranial aneurysms.Methods:Patients with unruptured intracranial aneurysms hospitalized in the First People's Hospital of Kashgar from January 2016 to September 2021 were retrospectively enrolled as the case group and patients with trigeminal neuralgia in the same period as the control group. The demographic and clinical data of patients were collected, and the correlation between serum cystatin C and the occurrence of intracranial aneurysms was determined by univariate and multivariate logistic regression analysis. Results:A total of 114 patients with unruptured intracranial aneurysms and 142 patients with trigeminal neuralgia were enrolled. Univariate analysis showed that there were significant differences in triglyceride and cystatin C, as well as the proportions of male and hypertensive patients between the case group and the control group (all P<0.05). Multivariate logistic regression analysis showed that there was a significant independent negative correlation between the serum cystatin C and the risk of intracranial aneurysms (odds ratio 0.045, 95% confidence interval 0.011-0.184; P<0.001). Conclusion:Serum cystatin C may be an independent protective factor for the formation of intracranial aneurysms.
ABSTRACT
Objective:To investigate the correlation between hyperhomocysteinemia (HHcy) and the onset of intracranial aneurysm (IAs).Methods:Patients with IA visited the Department of Neurosurgery, the First People's Hospital of Kashgar from February 2017 to November 2020 were retrospectively included as a case group, while patients with trigeminal neuralgia visited the hospital at the same time were selected as a control group. Demographic data, vascular risk factors and laboratory findings were compared between the two groups. Multivariate logistic regression analysis was used to determine the correlation between HHcy and IAs. Results:A total of 150 patients with IA (case group) and 112 patients with trigeminal neuralgia (control group) were included. Univariate analysis showed that there were significant differences in age, hypertension, drinking, triglyceride, low-density lipoprotein cholesterol, total Hcy and HHcy between the two groups (all P<0.05). Multivariate logistic regression analysis showed that there were significant independent correlation among males (odds ratio [ OR] 0.320, 95% confidence interval [ CI] 0.167-0.613; P=0.001), hypertension ( OR 4.915, 95% CI 2.674-9.036; P<0.001), triglycerides ( OR 1.342, 95% CI 1.030-1.750; P=0.030), total Hcy ( OR 1.171, 95% CI 1.082-1.268; P<0.001), HHcy ( OR 3.574, 95% CI 1.522-8.391; P=0.003) and IAs. Conclusion:HHcy is an independent risk factor for the increased risk of IAs.
ABSTRACT
Objective:To investigate the correlation between serum cystatin C (CysC), blood lipids and the risk of intracranial aneurysm (IA) rupture.Methods:Patients with saccular IA admitted to the First Affiliated Hospital of Xinjiang Medical University from December 2017 to May 2019 were enrolled retrospectively. The patients were divided into the ruptured group and the unruptured group. The correlation between CysC, lipids and IA rupture was identified by univariate and multivariate logistic regression analyses. Results:A total of 392 patients were enrolled, including 143 (36.5%) males and 249 (63.5%) females. Two hundred and seventy-eight patients (70.9%) were ruptured IAs, 114 (29.1%) were unruptured IAs. Univariate analysis showed that triglyceride (1.26±0.94 mmol/L vs. 2.12±1.45 mmol/L; t=5.872, P<0.001), apolipoprotein A-Ⅰ (0.95±0.29 g/L vs. 1.08±0.34 g/L; t=3.744, P<0.001 ), CysC (0.63±0.20 mg/L vs. 0.80±0.48 mg/L; t=3.650, P<0.001) level, and the proportions of hypertension (46.8% vs. 61.4%; χ2=6.938, P=0.008), hyperlipidemia (19.4% vs. 48.2%; χ2=32.493, P<0.001) and aneurysm diameter >7 mm (24.4% vs. 41.2%; χ2=11.504, P<0.001) of the ruptured group were significantly lower than those of the unruptured group, while the level of apolipoprotein B was significantly higher than that of the unruptured group (1.07±0.29 g/L vs. 0.99±0.30 g/L; t=2.417, P=0.016). Multivariate logistic regression analysis showed that aneurysm diameter ≤7 mm (odds ratio [ OR] 2.281, 95% confidence interval [ CI] 1.342-3.876; P=0.002), and the serum levels of triacylglycerol ( OR 0.484, 95% CI 0.333-0.705; P<0.001), apolipoprotein A-Ⅰ ( OR 0.248, 95% CI 0.105-0.587; P=0.002) and CysC ( OR 0.130, 95% CI 0.038-0.444; P=0.001) were significantly independently correlated with the risk of IA rupture. Conclusions:CysC, apolipoprotein A-Ⅰ and triacylglycerol are protective markers for IA rupture, and aneurysm diameter ≤7 mmis associated with IA rupture.